
Our story begins on October 8th, 2014, on a very special episode of the Late Show with David Letterman. He was ending that episode with a musical guest from Japan -- a holographic vocaloid named Hatsune Miku. Pay attention to Letterman's barely-veiled incredulity as he introduces her. He can't believe the words coming out of his mouth:
But what really makes this moment is the ending, after the performance. Letterman doesn't even know what to say, and he knows he doesn't know what to say. The experience was completely overwhelming, so Letterman has to somehow pivot back to interpret it for his audience (mostly moms and dads from Milwaukee) and all he can muster is a facile comparison to "being on Willie Nelson's bus." (Willie Nelson, if you're not familiar, is a celebrity notorious for his drug use, among other things.)
The meaning is both clear and agreeable: Hatsune Miku is drugs.